Healing Peptides
Cagrilintide
Cagrilintide is a long-acting analogue of amylin, a naturally occurring peptide that is released in conjunction with insulin. Cagrilintide has shown promise in animal trials as a treatment for obesity and type 2 diabetes. It has been studied for benefits not just in type 2 diabetes, but for liver damage, alcohol-related liver disease, and heart/blood vessel disease. There is some speculation about the role of this peptide in Alzheimer’s disease as well, but no research has been published in that particular sub-domain, yet. Many trials, however, have looked at the combination of cagrilintide and semaglutide in the treatment of obesity and type 2 diabetes. The two proteins appear to work synergistically to provide more robust and more permanent weight loss effects. It is important to note that while preclinical studies suggest promising therapeutic potential, clinical trials in humans are limited. Further research needs to be done to determine the efficacy and safety profiles.
GHK-CU
GHK-Cu is a natural peptide in human blood plasma, urine, and saliva. Research in animals reveals that GHK-Cu can improve wound healing, immune function, and skin health by stimulating collagen, fibroblasts and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. It also suppresses free-radical damage and thus is a potent antioxidant.
MT-1
Melanotan 1 is similar to naturally occurring alpha melanocyte stimulating hormone alpha-MSH (Melanotan 2). Alpha-MSH is known for its influence on melanocytes, the cells in skin and hair responsible for pigmentation. This function is mediated via strong binding to melanocortin receptor 1. Alpha-MSH is a non-selective full agonist of melanocortin receptors 1, 3, 4, and 5. Melanotan 1 differs from alpha-MSH (Melanotan 2) by a single amino acid and was actually first developed as a sunless tanning agent. Research into melanocortin receptors and their effects, scientists quickly discovered that while melanotan 1 did indeed cause pigmentation, and altered baseline metabolism. Subsequent study of melanotan 1 and other melanocortin-binding proteins helped scientists to better understand the melanocortin signaling system.
MT-2
Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Developed in the 1980s, Melanotan-2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger and increase melanin production. Research has shown the peptide to stimulate melanocytes therefore producing increased skin pigmentation and may help to combat autism when used during early childhood development.
PT-141(Bremelanotide )
PT-141, also called Bremelanotide (generic clinical name), is a heavily modified synthetic derivative of alpha-melanocyte-stimulating hormone. It has been tested in clinical trials as a treatment for both male/female hypoactive sexual desire disorder and acute hemorrhage. PT-141 is an agonist for the melanocortin-4 and melanocortin-1 receptors. Research shows that it promotes sexual arousal and stimulates the immune system.
TB500
TB-500 (Thymosin Beta-4) is a 43 amino acid peptide sequence. In animal models, Thymosin Beta-4 has been shown to improve blood vessel growth, regulate wound healing, decrease inflammation, and reduce oxidative damage in the heart and central nervous system. Thymosin-beta-4 has a role in protection, tissue repair, regeneration and remodeling of injured or damaged tissues. It is also of active interest in anti-aging research.
BPC 157
BPC-157, or Body Protection Compound 157, is a synthetic peptide composed of 15 amino acids. It is derived from a protective protein found in the human gastric juice and has been widely studied for its potential therapeutic properties. BPC-157 is known for its regenerative capabilities, with research suggesting its role in promoting healing across various tissues, including muscles, tendons, ligaments, and even the gastrointestinal (GI) tract. This peptide has gained attention in scientific and medical communities due to its wide-ranging biological effects and potential applications in treating injuries, chronic conditions, and inflammatory diseases.
BPC 5mg + TB 5mg
BPC-157 and TB-500 (Thymosin Beta-4) are peptides commonly studied for their potential in promoting tissue repair and healing. Both have distinct yet complementary mechanisms that, when combined, may offer synergistic benefits. BPC-157, a stable gastric pentadecapeptide, is derived from a protective protein found in the stomach lining. It has been shown in preclinical studies to accelerate healing of muscles, tendons, and ligaments by promoting angiogenesis (the formation of new blood vessels) and regulating the production of growth factors. Similarly, TB-500, a fragment of the naturally occurring Thymosin Beta-4 protein, plays a key role in cell migration, tissue regeneration, and reducing inflammation.
The potential synergy between these peptides arises from their overlapping yet distinct pathways in tissue repair. While BPC-157 excels at improving blood flow and reducing inflammation, TB-500 focuses on facilitating cellular migration to the injury site and supporting the repair process at the cellular level. Together, they may accelerate healing by addressing multiple aspects of tissue recovery, particularly in sports injuries or chronic conditions where regeneration is compromised. Early animal studies suggest this combination may lead to faster recovery times and improved structural integrity of repaired tissues.
It is crucial to note that while promising, much of the research on BPC-157 and TB-500 remains preclinical.
Semax
Semax is a synthetic derivative of adrenocorticotrophic hormone. Research suggests that it can increase BDNF and may help improve immune function, protect neurons, and improve cardiovascular function. It may also be beneficial in pain control and blood clotting.
Selank
Selank peptide is a short, synthetic analogue of tuftsin. It has profound anti-anxiety properties. Selank also boosts memory and learning and has been shown to have beneficial effects on pain perception.
Selank is a short, synthetic analogue of tuftsin. It has profound anti-anxiety properties. Selank also boosts memory and learning and has been shown to have beneficial effects on pain perception.
SS-31
SS-31 helps improve mitochondrial function and overall production of energy via ATP synthesis. Research has shown its ability to reduce inflammatory cytokines which cause oxidative stress and inflammatory diseases such as Alzheimer’s, Parkinson’s, heart disease, diabetes, kidney disease, and more
GHRP-2 Acetate
GHRP-2 is a synthetic growth hormone secretagogue that binds to the ghrelin/growth hormone secretagogue receptor. It has been shown in research trials to improve muscle growth, regulate the immune system, and improve sleep cycles. GHRP-2 research has shown that it has oral bio-activity.
GHRP-6 Acetate
GHRP-6 is a synthetic ghrelin/growth hormone secretagogue agonist. It has positive effects on appetite, heart muscle cells, scar formation, and sexual motivation. Animal studies show this orally active growth hormone secretagogue also improves memory function and may help to thwart the neurological effects of Parkinson’s disease.
Sermorelin Acetate
Sermorelin is a growth-hormone-releasing hormone (GHRH) analogue that has been used to assess and stimulate natural growth hormone secretion. It is of interest to researchers for its ability to improve bone density, reduce scaring, fight the effects of dementia, and reduce seizure activity.
AOD9604
AOD9604 is a modified version of the hGH fragment 176-191 peptide (contains a di-sulfide bridge) and thus a derivative of human growth hormone (hGH). Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome. AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis in animal studies.
Tesamorelin
Tesamorelin, is a syntheitic peptide consiting of 44 amino acids. It is a growth-hormone-releasing hormone (GHRH) analogue researched for the treatment of HIV-associated lipodystrophy (dysfunctional, toxic fat deposition). It is also being researched for its ability to improve peripheral nerve health, slow the progression of mild cognitive impairment, and the reduction visceral fat. This peptide has been found to reduce adiposity by nearly 20% in this population [1]. Research suggests that tesamorelin is approximately 4 times more effective in reducing adiposity than all of the other available therapies combined [2].
Ipamorelin
Ipamorelin is a short peptide sequence capable of binding to the ghrelin/growth hormone secretagogue receptor. It is one of the most selective growth hormone (GH) secretagogues known and has been shown in laboratory studies to have no effect on ACTH, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, or cortisol release [1]. Given its high level of specificity, ipamorelin has been of interest in research both as a therapeutic in and of itself as well as a model peptide for understanding how selectivity in GH receptor binding is achieved. Its presence plays a key role in the overall growth and repair of musculoskeletal tissue.
KissPeptin-10
Kisspeptin acts to control hormone secretion as it relates to reproduction. Kisspeptin has been shown to influence testosterone levels and sex-related behaviors like drive and motivation. Research also suggests it may help to reverse some of the effects of aging.
KPV
KPV is a potent anti-inflammatory peptide that has shown promise in a number of disease conditions. The most active research is in the treatment of inflammatory bowel disease where the peptide has showed substantial promise. Research in wound healing also reveals that KPV and other alpha-MSH derivatives may offer a host of benefits that speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV and similar peptides could become mainstays not just in wound healing, but in scar reduction following surgery.
MOTS-c
MOTS-c is a small protein made in the mitochondria, often referred to as the cell's powerhouse, and it helps regulate how our cells use energy. By affecting how the body processes glucose and responds to insulin, MOTS-c plays a role in maintaining a healthy balance in metabolism. It works by moving to the cell’s nucleus, where it influences certain genes related to energy production and stress response, especially when the body is under metabolic stress. Research suggests MOTS-c may help support better glucose control and could be useful in addressing metabolic issues and age-related health concerns. MOTS-c has been shown to promote metabolic homeostasis and longevity, & improve exercise capacity, reduce obesity, insulin resistance and other disease processes such as osteoporosis.
Glutathione
Glutathione is a potent anti-oxidant and regulator of a number of biochemical processes. It is abundant in human tissues, but subject to decline with aging. Research shows that glutathione can help to reduce neurodegenerative disease, promote cartilage health, ward off age-related changes in the eye, improve immune function, and maintain more youthful skin. Overall, there is robust evidence that glutathione is a potent anti-aging compound with extensive immune and health benefits.
CJC-1295 With DAC
CJC-1295 is a synthetic analogue of growth hormone releasing hormone (GHRH) that increases plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1). DAC is an additive moiety that prolongs the plasma half-life of CJC-1295.
CJC-1295 without DAC 5mg +IPA 5mg
CJC-1295 5mg, Ipamorelin 5mg (10mg Total Peptide Blend)
CJC-1295 causes the natural release of GH, but it does so by naturally stimulating the growth hormone releasing hormone receptor.
Ipamorelin is one of the most selective growth hormone (GH) secretagogues known and a potent agonist of the ghrelin/growth hormone secretagogue receptor. It has been heavily researched in a number of settings and is known to improve bone health, boost muscle repair and development, stimulate insulin release from the pancreas, and improve bowel motility and gastric function.
CJC-1295 when combined with Ipamorelin has been shown to exhibit synergistic effects when researched together.
Ara-290
ARA-290 is a variant of erythropoietin which has been shown to decrease inflammatory pathways through paracrine signalling and the innate repair receptors. Research has shown ARA-290 to help reduce HbA1c, improve cholesterol, modulate neuropathic pain and stimulate wound repair.
Thymalin
Thymalin is a synthetic version of Thymulin, which is involved in regulating inflammation and pain. Research shows that Thymalin may be effective in boosting immune function, fighting heart disease, and regulating sleep-wake cycles. It is also of interest in aging research for its ability to reduce all-cause mortality in mouse models and prolong lifespan.
Thymosin Alpha-1
Thymosin Alpha-1 is a natural regulator of immune function. It has since been studied for cystic fibrosis, infection (e.g. tuberculosis, cytomegalovirus), respiratory disorders, chronic hepatitis, and cancer. Thymosin alpha-1 was first discovered in 1972 and was isolated from tissue of the thymus gland and is a potent immune function modulator.
LL37
LL-37, Like all Cathelicidins, has antimicrobial, antibacterial, antiviral, anti-fungal and has been shown to reduce inflammation. Research has also shown that its effect against certain cancers and encourages blood vessel growth in specific settings.
Pinealon
Pinealon is a synthetic peptide just three amino acids in length. It has been shown to modify behavior and protect a number of cell types against the effects of hypoxia. It has undergone extensive research for its ability to alter circadian rhythm, improve memory, and enhance learning. It has been shown to offset the effects of aging, particularly in the central nervous system, and may be useful in treating cognitive disorders like Alzheimer’s disease.
IGF-1LR3
IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetic, modified construct of insulin-like growth factor-1. Because IGF-1 LR3 does not bind to IGF-1 binding proteins very well, it remains active up to 120 times longer than standard IGF-1. This results in improved half-life for the peptide and thus increased activity. IGF-1 LR3 enhances cell division and growth, boosts fat metabolism, and increases muscle repair and hypertrophy by inhibiting myostatin. Recent research suggests that IGF-1 LR3 may also be useful in improving lactation among mothers with young offspring.
IGF-DES
IGF-1 DES is a truncated, natural version (splice variant) of insulin-like growth factor-1 Naturally found in the brain, breast milk, and uterine tissue, IGF-1 DES stimulates hypertrophy and hyperplasia of a number of different cell lines. Research has shown this version of the protein to be more potent than standard IGF-1, mostly as a result of its enhanced bioavailability. Currently, researchers are looking at ways to utilize IGF-1 DES in the treatment of inflammatory bowel disease (IBD), autism, and a variety of neurological conditions. Research shows that it helps to maintain the health of synaptic connections in the central nervous system and, like all IGF-1, promotes the repair of muscle and connective tissue.
VIP(vasoactive intestinal polypeptide)
Research shows that VIP can help to reduce inflammation throughout the body, but that it is particularly useful in the setting of neurodegenerative disease, pulmonary fibrosis, inflammatory bowel disease, and cardiac fibrosis. The peptide appears to be highly effective in a number of fibrotic pathways and may offer treatment benefits in the common process of fibrosis that leads to so much morbidity and mortality.
In addition to its antifibrotic effects, which appear to be mediated through anti-inflammatory actions, VIP is also a potent immune system regulator and general anti-inflammatory. The peptide has also been shown to protect the central nervous system against insult and is of active interest for its ability to preserve cognitive function in the setting of neurodegenerative disease.
SLU-PP-332
SLU-PP-332 is an experimental compound designed to mimic the metabolic effects of exercise by activating estrogen-related receptors (ERRs), particularly ERRα, ERRβ, and ERRγ. This activation leads to increased energy expenditure, enhanced fatty acid oxidation, and improved mitochondrial function.
Epithalon
Epithalon (Epitalon) is a synthetic derivative of Epithalamin and a potential modulator of telomerase, the enzyme that maintains and protects the telomere caps at the ends of chromosomes (strands of DNA). Research suggests that Epithalon induces telomere elongation and may fight off the effects of aging as a result.
DSIP
Delta-sleep-inducing peptide is a neuropeptide that affects a number of endocrine and physiological processes within the central nervous system. DSIP is of primary interest for its abilities to reduce oxidative stress, normalize myocardial contractility. It is also being studied as a potential target in the treatment of major depressive disorder.
HGH(HG)
HGH Fragment 176-191 is a small, synthetic piece of natural human growth hormone (hGH). It is often referred to as the “lipolytic fragment” for its ability to boost fat loss. It has been shown to help lower blood sugar levels and promote cartilage healing without increasing long bone growth, increasing IGF-1 levels, or altering insulin sensitivity.
5-amino-1mq
5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1).
SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer. Research in mice given 5-amino-1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake, compared to controls. Research has shown that decreasing NNMT may help shrink fat cells and reduce the size of fat deposits.
PE22-28
PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin which binds to TREK-1. TREK-1 is found in regions of the brain controlling mood, memory, and learning. PE-22-28 is being researched for applications including antidepressant activity, learning, stroke recovery and neurodegenerative diseases such as Alzheimer’s.
Testagen
Testagen is a short, bioregulatory peptide that has primary effects on the pituitary gland and ultimately the thyroid gland. As a result of its action on these two glands, Testagen is capable of normalizing testosterone production as well as thyroid hormone production in certain settings. By normalizing thyroid hormone production, Testagen has a moderate impact on the immune system. In these cases, Testagen can be conveniently thought of as resetting the pituitary gland to a more youthful state and thereby acting as an anti-aging peptide. Testagen is being researched for its ability to boost testosterone levels, improve thyroid hormone function, and stimulate the differentiation of stem cells in the immune system to improve immune function.
B12
B12 injections offer numerous benefits, primarily due to their ability to effectively address B12 deficiencies and provide a quick boost to the body. These injections can improve energy levels, boost brain function, enhance mood, and support overall health