Anti Aging Peptides
The best anti-aging injectable peptides target skin rejuvenation, collagen and elastin production, and overall cellular repair. Here are the most effective and widely used options:
NAD
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging.
Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+'s importance in cellular integrity and combating aging.
GHK-CU
GHK-Cu is a natural peptide in human blood plasma, urine, and saliva. Research in animals reveals that GHK-Cu can improve wound healing, immune function, and skin health by stimulating collagen, fibroblasts and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. It also suppresses free-radical damage and thus is a potent antioxidant.
MT-1
Melanotan 1 is similar to naturally occurring alpha melanocyte stimulating hormone alpha-MSH (Melanotan 2). Alpha-MSH is known for its influence on melanocytes, the cells in skin and hair responsible for pigmentation. This function is mediated via strong binding to melanocortin receptor 1. Alpha-MSH is a non-selective full agonist of melanocortin receptors 1, 3, 4, and 5. Melanotan 1 differs from alpha-MSH (Melanotan 2) by a single amino acid and was actually first developed as a sunless tanning agent. Research into melanocortin receptors and their effects, scientists quickly discovered that while melanotan 1 did indeed cause pigmentation, and altered baseline metabolism. Subsequent study of melanotan 1 and other melanocortin-binding proteins helped scientists to better understand the melanocortin signaling system.
MT-2
Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Developed in the 1980s, Melanotan-2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger and increase melanin production. Research has shown the peptide to stimulate melanocytes therefore producing increased skin pigmentation and may help to combat autism when used during early childhood development.
PT-141(Bremelanotide )
PT-141, also called Bremelanotide (generic clinical name), is a heavily modified synthetic derivative of alpha-melanocyte-stimulating hormone. It has been tested in clinical trials as a treatment for both male/female hypoactive sexual desire disorder and acute hemorrhage. PT-141 is an agonist for the melanocortin-4 and melanocortin-1 receptors. Research shows that it promotes sexual arousal and stimulates the immune system.
TB500
TB-500 (Thymosin Beta-4) is a 43 amino acid peptide sequence. In animal models, Thymosin Beta-4 has been shown to improve blood vessel growth, regulate wound healing, decrease inflammation, and reduce oxidative damage in the heart and central nervous system. Thymosin-beta-4 has a role in protection, tissue repair, regeneration and remodeling of injured or damaged tissues. It is also of active interest in anti-aging research.
BPC 157
BPC-157, or Body Protection Compound 157, is a synthetic peptide composed of 15 amino acids. It is derived from a protective protein found in the human gastric juice and has been widely studied for its potential therapeutic properties. BPC-157 is known for its regenerative capabilities, with research suggesting its role in promoting healing across various tissues, including muscles, tendons, ligaments, and even the gastrointestinal (GI) tract. This peptide has gained attention in scientific and medical communities due to its wide-ranging biological effects and potential applications in treating injuries, chronic conditions, and inflammatory diseases.
BPC 5mg + TB 5mg
BPC-157 and TB-500 (Thymosin Beta-4) are peptides commonly studied for their potential in promoting tissue repair and healing. Both have distinct yet complementary mechanisms that, when combined, may offer synergistic benefits. BPC-157, a stable gastric pentadecapeptide, is derived from a protective protein found in the stomach lining. It has been shown in preclinical studies to accelerate healing of muscles, tendons, and ligaments by promoting angiogenesis (the formation of new blood vessels) and regulating the production of growth factors. Similarly, TB-500, a fragment of the naturally occurring Thymosin Beta-4 protein, plays a key role in cell migration, tissue regeneration, and reducing inflammation.
The potential synergy between these peptides arises from their overlapping yet distinct pathways in tissue repair. While BPC-157 excels at improving blood flow and reducing inflammation, TB-500 focuses on facilitating cellular migration to the injury site and supporting the repair process at the cellular level. Together, they may accelerate healing by addressing multiple aspects of tissue recovery, particularly in sports injuries or chronic conditions where regeneration is compromised. Early animal studies suggest this combination may lead to faster recovery times and improved structural integrity of repaired tissues.
It is crucial to note that while promising, much of the research on BPC-157 and TB-500 remains preclinical
Semax
Semax is a synthetic derivative of adrenocorticotrophic hormone. Research suggests that it can increase BDNF and may help improve immune function, protect neurons, and improve cardiovascular function. It may also be beneficial in pain control and blood clotting.
Selank
Selank peptide is a short, synthetic analogue of tuftsin. It has profound anti-anxiety properties. Selank also boosts memory and learning and has been shown to have beneficial effects on pain perception.
Selank is a short, synthetic analogue of tuftsin. It has profound anti-anxiety properties. Selank also boosts memory and learning and has been shown to have beneficial effects on pain perception.
SS-31
SS-31 helps improve mitochondrial function and overall production of energy via ATP synthesis. Research has shown its ability to reduce inflammatory cytokines which cause oxidative stress and inflammatory diseases such as Alzheimer’s, Parkinson’s, heart disease, diabetes, kidney disease, and more
GHRP-2 Acetate
GHRP-2 is a synthetic growth hormone secretagogue that binds to the ghrelin/growth hormone secretagogue receptor. It has been shown in research trials to improve muscle growth, regulate the immune system, and improve sleep cycles. GHRP-2 research has shown that it has oral bio-activity.
GHRP-6 Acetate
GHRP-6 is a synthetic ghrelin/growth hormone secretagogue agonist. It has positive effects on appetite, heart muscle cells, scar formation, and sexual motivation. Animal studies show this orally active growth hormone secretagogue also improves memory function and may help to thwart the neurological effects of Parkinson’s disease.
Sermorelin Acetate
Sermorelin is a growth-hormone-releasing hormone (GHRH) analogue that has been used to assess and stimulate natural growth hormone secretion. It is of interest to researchers for its ability to improve bone density, reduce scaring, fight the effects of dementia, and reduce seizure activity.
AOD9604
AOD9604 is a modified version of the hGH fragment 176-191 peptide (contains a di-sulfide bridge) and thus a derivative of human growth hormone (hGH). Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome. AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis in animal studies.
Tesamorelin
Tesamorelin, is a syntheitic peptide consiting of 44 amino acids. It is a growth-hormone-releasing hormone (GHRH) analogue researched for the treatment of HIV-associated lipodystrophy (dysfunctional, toxic fat deposition). It is also being researched for its ability to improve peripheral nerve health, slow the progression of mild cognitive impairment, and the reduction visceral fat. This peptide has been found to reduce adiposity by nearly 20% in this population [1]. Research suggests that tesamorelin is approximately 4 times more effective in reducing adiposity than all of the other available therapies combined [2].
Ipamorelin
Ipamorelin is a short peptide sequence capable of binding to the ghrelin/growth hormone secretagogue receptor. It is one of the most selective growth hormone (GH) secretagogues known and has been shown in laboratory studies to have no effect on ACTH, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, or cortisol release [1]. Given its high level of specificity, ipamorelin has been of interest in research both as a therapeutic in and of itself as well as a model peptide for understanding how selectivity in GH receptor binding is achieved. Its presence plays a key role in the overall growth and repair of musculoskeletal tissue.
KissPeptin-10
Kisspeptin acts to control hormone secretion as it relates to reproduction. Kisspeptin has been shown to influence testosterone levels and sex-related behaviors like drive and motivation. Research also suggests it may help to reverse some of the effects of aging.
KPV
KPV is a potent anti-inflammatory peptide that has shown promise in a number of disease conditions. The most active research is in the treatment of inflammatory bowel disease where the peptide has showed substantial promise. Research in wound healing also reveals that KPV and other alpha-MSH derivatives may offer a host of benefits that speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV and similar peptides could become mainstays not just in wound healing, but in scar reduction following surgery.
MOTS-c
MOTS-c is a small protein made in the mitochondria, often referred to as the cell's powerhouse, and it helps regulate how our cells use energy. By affecting how the body processes glucose and responds to insulin, MOTS-c plays a role in maintaining a healthy balance in metabolism. It works by moving to the cell’s nucleus, where it influences certain genes related to energy production and stress response, especially when the body is under metabolic stress. Research suggests MOTS-c may help support better glucose control and could be useful in addressing metabolic issues and age-related health concerns. MOTS-c has been shown to promote metabolic homeostasis and longevity, & improve exercise capacity, reduce obesity, insulin resistance and other disease processes such as osteoporosis.
Glutathione
Glutathione is a potent anti-oxidant and regulator of a number of biochemical processes. It is abundant in human tissues, but subject to decline with aging. Research shows that glutathione can help to reduce neurodegenerative disease, promote cartilage health, ward off age-related changes in the eye, improve immune function, and maintain more youthful skin. Overall, there is robust evidence that glutathione is a potent anti-aging compound with extensive immune and health benefits.
snap-8
Reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.
A safer, cheaper, and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way
Has been incorporated in cosmetic formulations such as emulsions, gels, sera, etc.where removal of the deep lines or wrinkles in the forehead or around the eyes area is desired.
VIP(vasoactive intestinal polypeptide)
Research shows that VIP can help to reduce inflammation throughout the body, but that it is particularly useful in the setting of neurodegenerative disease, pulmonary fibrosis, inflammatory bowel disease, and cardiac fibrosis. The peptide appears to be highly effective in a number of fibrotic pathways and may offer treatment benefits in the common process of fibrosis that leads to so much morbidity and mortality.
In addition to its antifibrotic effects, which appear to be mediated through anti-inflammatory actions, VIP is also a potent immune system regulator and general anti-inflammatory. The peptide has also been shown to protect the central nervous system against insult and is of active interest for its ability to preserve cognitive function in the setting of neurodegenerative disease.
SLU-PP-332
SLU-PP-332 is an experimental compound designed to mimic the metabolic effects of exercise by activating estrogen-related receptors (ERRs), particularly ERRα, ERRβ, and ERRγ. This activation leads to increased energy expenditure, enhanced fatty acid oxidation, and improved mitochondrial function.
Epithalon
Epithalon (Epitalon) is a synthetic derivative of Epithalamin and a potential modulator of telomerase, the enzyme that maintains and protects the telomere caps at the ends of chromosomes (strands of DNA). Research suggests that Epithalon induces telomere elongation and may fight off the effects of aging as a result.
DSIP
Delta-sleep-inducing peptide is a neuropeptide that affects a number of endocrine and physiological processes within the central nervous system. DSIP is of primary interest for its abilities to reduce oxidative stress, normalize myocardial contractility. It is also being studied as a potential target in the treatment of major depressive disorder.
HGH(HG)
HGH Fragment 176-191 is a small, synthetic piece of natural human growth hormone (hGH). It is often referred to as the “lipolytic fragment” for its ability to boost fat loss. It has been shown to help lower blood sugar levels and promote cartilage healing without increasing long bone growth, increasing IGF-1 levels, or altering insulin sensitivity.
5-amino-1mq
5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1).
PE22-28
PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin which binds to TREK-1. TREK-1 is found in regions of the brain controlling mood, memory, and learning. PE-22-28 is being researched for applications including antidepressant activity, learning, stroke recovery and neurodegenerative diseases such as Alzheimer’s.
Testagen
Testagen is a short, bioregulatory peptide that has primary effects on the pituitary gland and ultimately the thyroid gland. As a result of its action on these two glands, Testagen is capable of normalizing testosterone production as well as thyroid hormone production in certain settings. By normalizing thyroid hormone production, Testagen has a moderate impact on the immune system. In these cases, Testagen can be conveniently thought of as resetting the pituitary gland to a more youthful state and thereby acting as an anti-aging peptide. Testagen is being researched for its ability to boost testosterone levels, improve thyroid hormone function, and stimulate the differentiation of stem cells in the immune system to improve immune function.
B12
B12 injections offer numerous benefits, primarily due to their ability to effectively address B12 deficiencies and provide a quick boost to the body. These injections can improve energy levels, boost brain function, enhance mood, and support overall health
Peptides offer several potential benefits for DNA and cell repair, making them a promising option in regenerative medicine and anti-aging therapies:
Enhancement of DNA Repair Mechanisms: Certain peptides, such as GHK-Cu and Epitalon, have been shown to promote DNA repair by upregulating genes related to cellular repair and restoration. GHK-Cu, for example, can reset gene expression patterns to a healthier state and stimulate the expression of DNA repair genes, helping cells recover from damage.
Cellular Regeneration and Anti-Aging: Peptides like GHK-Cu and BPC-157 support tissue remodeling, collagen synthesis, and wound healing. They can also boost mitochondrial function, which is crucial for cellular energy and overall cell health.
Improved Tissue Healing: Injectable peptides can accelerate wound healing, reduce inflammation, and promote the growth of new blood vessels. GHK-Cu, in particular, has demonstrated strong regenerative effects in skin, bone, and other tissues.
Telomere Protection: Peptides such as Epitalon may help lengthen telomeres (the protective ends of chromosomes), which are associated with cellular aging and DNA stability.
Overall, injectable peptides can help maintain cellular integrity, support DNA repair, and promote tissue regeneration, potentially slowing the aging process and improving recovery from injury or cellular damage
Here are some notable peptides and peptide-based compounds associated with DNA and cell repair, based on current research and clinical use:
GHK-Cu (Copper Tripeptide-1): Stimulates DNA repair, tissue remodeling, and collagen synthesis. It is widely used in skin care and regenerative medicine for its ability to reset gene expression to a healthier state and promote cellular repair.
Epitalon: A synthetic peptide derived from the pineal gland that may help protect telomeres, support DNA stability, and promote longevity.
BPC-157: Known for its regenerative effects on tissues, wound healing, and anti-inflammatory properties, though its direct role in DNA repair is less established than its cell repair benefits.
NAD+ (nicotinamide adenine dinucleotide):
It is a vital coenzyme in all cells that plays a crucial role in DNA repair and maintaining genomic stability. Here are its key benefits for DNA repair:
Supports Multiple DNA Repair Pathways: NAD+ is required as a substrate by several DNA repair enzymes, including PARP1, PARP2, and sirtuins, which are involved in base excision repair, double-strand break repair, and other mechanisms.
Enhances Genomic Stability: Adequate NAD+ levels help prevent the accumulation of DNA damage, which is linked to aging and age-related diseases.
Boosts Cellular Resilience to Damage: Supplementing with NAD+ or its precursors (such as NMN and NR) can improve DNA repair efficiency, especially in conditions of accelerated aging or following exposure to DNA-damaging agents.
Reduces Age-Related DNA Damage: Declining NAD+ levels with age are associated with reduced DNA repair capacity; increasing NAD+ can help restore this function and may slow certain effects of aging.
Protects Against Disease: NAD+ supplementation has shown promise in reducing DNA damage and improving outcomes in diseases linked to impaired DNA repair, such as certain neurodegenerative and progeroid syndromes.